This tumor is more common in larger breeds of dog. Some breeds have far more cancers than others, often of specific types. They do this by activating growth-promoting oncogenes (cancer genes), inactivating suppressor genes and altering the genes that regulate normal, programmed cell death (apoptosis). The mutated cells upset the normal regulation of cell death and replacement. It is the result of non-lethal genetic damage to cells, with "external" contributory factors such as radiation, chemicals, hormones and infections.
#Spindle cell sarcoma in dogs series
Cancer is often the culmination of a series of circumstances that come together for the unfortunate individual. Little is known about the cause of these tumors. The tumors often recur locally after surgical removal but spread to other parts of the body (metastasis) is rare. Therefore, these connective tissue tumors may have several different names, including fibrosarcoma, schwannoma, neurofibroma, peripheral nerve sheath tumor, and hemangiopericytoma. Some pathologists try to classify this group of tumors by their cells of origin, but this is not always possible. The tumor is diverse in appearance and several different cell lines produce tumors of similar appearance. If you have any questions please do not hesitate to ask your veterinarian.įibrosarcomas and spindle cell tumors originate from the connective tissue of, or beneath, the skin. However, information and understanding about tumors and their treatment in animals is improving all the time. Because individual situations and responses vary, and because cancers often behave unpredictably, science can only give us a guide. Your veterinarian may suggest certain tests to help confirm or eliminate diagnosis, and to help assess treatment options and likely outcomes. For general information on cancer in pets ask for our handout "What is Cancer". The results of this retrospective study indicate that many spindle cell tumours managed in first opinion practice exhibit a low-grade biological behaviour and may respond well to more conservative surgery than current recommendations advise.These notes are provided to help you understand the diagnosis or possible diagnosis of cancer in your pet. A palpable assessment of tumour invasion into underlying tissues was significantly associated with decreased disease-free interval (P<0.0001) and survival time (P = 0.0070). Tumour size, location or degree of surgical resection were not significantly related to survival or tumour recurrence. Most deaths were unrelated to sarcoma (50 dogs, 60.2 per cent) or unknown (15 dogs, 18 per cent). Eighteen dogs (21.7 per cent) died of tumour-related causes. Tumours recurred locally in 29 dogs (27.9 per cent). Excision margins of 3 cm or more were described in less than 10 per cent of cases. The method of surgical resection was described as marginal in 45 dogs (44.2 per cent). Questionnaires were sent to the submitting veterinarians, requesting details about the tumour, surgery performed and ultimate outcome of the patient. To define the outcome of a cohort of canine patients with a histological diagnosis of spindle cell tumour of soft tissue managed solely by surgery in first opinion practice.Ĭlinical details of 104 spindle cell sarcomas submitted to Finn Pathologists during the year 2000 were reviewed.
0 kommentar(er)
